COVID-19 Thread 3/28/2020 (French Follow-up Study of Hydrochloroquine Treatment, Plasma Treatment Study Published)

There has been a new study published by the French group of researchers studying the use of hydroxychloroquine and azithromycin to treat COVID-19 patients:

“Clinical and microbiological effect of a combination of hydroxychloroquine and azithromycin in 80 COVID-19 patients with at least a six-day follow up: an observational study”

From the abstract:

We need an effective treatment to cure COVID-19 patients and to decrease the virus carriage duration. In 80 in-patients receiving a combination of hydroxychloroquine and azithromycin we noted a clinical improvement in all but one 86 year-old patient who died, and one 74 year-old patient still in intensive care unit. A rapid fall of nasopharyngeal viral load tested by qPCR was noted, with 83% negative at Day7, and 93% at Day8. Virus cultures from patient respiratory samples were negative in 97.5% patients at Day5. This allowed patients to rapidly de discharge from highly contagious wards with a mean length of stay of five days.

https://www.mediterranee-infection.com/wp-content/uploads/2020/03/COVID-IHU-2-1.pdf

Also, a study has been published about treating COVID-19 patients with plasma from patients who have recovered from the disease:

“Treatment of 5 Critically Ill Patients With COVID-19 With Convalescent Plasma”
JAMA. Published online March 27, 2020. doi:10.1001/jama.2020.4783

From the Results section of the study:

All 5 patients (age range, 36-65 years; 2 women) were receiving mechanical ventilation at the time of treatment and all had received antiviral agents and methylprednisolone. Following plasma transfusion, body temperature normalized within 3 days in 4 of 5 patients, the SOFA score decreased, and Pao2/Fio2 increased within 12 days (range, 172-276 before and 284-366 after). Viral loads also decreased and became negative within 12 days after the transfusion, and SARS-CoV-2–specific ELISA and neutralizing antibody titers increased following the transfusion (range, 40-60 before and 80-320 on day 7). ARDS resolved in 4 patients at 12 days after transfusion, and 3 patients were weaned from mechanical ventilation within 2 weeks of treatment. Of the 5 patients, 3 have been discharged from the hospital (length of stay: 53, 51, and 55 days), and 2 are in stable condition at 37 days after transfusion.

https://jamanetwork.com/journals/jama/fullarticle/2763983

 

 

This site uses cookies. By continuing to browse the site you are agreeing to our use of cookies.